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Comment
. 2013 Dec 9;27(5):485-7.
doi: 10.1016/j.devcel.2013.11.020.

Wnt and Bmp fit germ cells to a T

Andrea V Cantú  1 , Diana J Laird  2
Affiliations
Comment

Wnt and Bmp fit germ cells to a T

Andrea V Cantú et al. Dev Cell. .

Abstract

Reporting in Developmental Cell, Aramaki et al. (2013) identify T as a key mediator of primordial germ cell (PGC) specification in the embryo. Deconstruction of how Bmp and Wnt signals regulate the expression and targeting of T to regulatory elements of either mesodermal or PGC genes has implications for differentiation in vitro.

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Figures

Figure 1
Figure 1. Model of PGC/mesoderm fate choice
Mouse PGCs are specified in the posterior corner of the proximal epiblast where Bmp4 (blue) and Wnt3 (yellow) signals converge. Neighboring mesodermal cells do not receive high levels of Bmp signals, preventing their specification to the germ cell lineage.
See this image and copyright information in PMC

Comment on

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