doi: 10.1016/j.bmcl.2013.11.054.
Epub 2013 Dec 4.
Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa
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- PMID: 24332092
- DOI: 10.1016/j.bmcl.2013.11.054
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Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa
Bioorg Med Chem Lett.
.
Abstract
Pyochelin is a siderophore common to all strains of Pseudomonas aeruginosa utilized by this Gram-negative bacterium to acquire iron(III). FptA is the outer membrane transporter responsible of ferric-pyochelin uptake in P. aeruginosa. We describe in this Letter the synthesis and the biological properties ((55)Fe uptake, binding to FptA) of several thiazole analogues of pyochelin. Among them we report in this Letter the two first pyochelin analogues able to bind FptA without promoting any iron uptake in P. aeruginosa.
Keywords: FptA; Outer membrane transporter; Pseudomonas aeruginosa; Pyochelin; Siderophore.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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