[Application of oxytocin antagonists in thaw embryo transfer]

Abstract

Objective: To study the effects of oxytocin antagonists-atosiban on pregnancy outcome after thaw embryo transfer (TET).

Methods: Between Jul. and Dec. 2012, a total of 120 women undergoing TET in Reproductive Medical Center, General Hospital of Tianjin Medical University were randomly allocated into atosiban and control group. They were all transferred 2 or 3 top quality embryos at phase of 7-8 cells . Patients in atosiban group were administered by intravenous administration of atosiban before 30 minutes of embryo transfer with a total administered dose of 37.5 mg. In the control group, no special treatment was given before embryo transfer. All patients in 2 groups underwent progesterone luteal support regularly after embryo transfer, then the clinical rate of pregnancy, implantation and early abortion was compared.

Results: The clinical pregnancy rate per cycle and implantation rate per transfer were 60% (36/60) and 30.0% (48/160) in the atosiban group, which were higher than 42% (25/60) and 20.3% (31/153) in the control group (all P < 0.05). Early abortion rate was 6% (2/36) in the atosiban group, which was no statistical difference comapring with control group [16% (4/25), P > 0.05].

Conclusion: It was suggested that atosiban treatment before embryo transfer can improve the outcome of pregnancy, and increase clinical pregnancy rate and implantation rate after TET.