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Review
. 2014 Mar;164(3):451-7.e1.
doi: 10.1016/j.jpeds.2013.10.086. Epub 2013 Dec 12.

An approach to the identification of anomalies and etiologies in neonates with identified or suspected VACTERL (vertebral defects, anal atresia, tracheo-esophageal fistula with esophageal atresia, cardiac anomalies, renal anomalies, and limb anomalies) association

Benjamin D Solomon  1 , Linda A Baker  2 , Kelly A Bear  3 , Bridget K Cunningham  3 , Philip F Giampietro  4 , Colleen Hadigan  5 , Donald W Hadley  6 , Steven Harrison  2 , Marc A Levitt  7 , Nickie Niforatos  8 , Scott M Paul  9 , Cathleen Raggio  10 , Heiko Reutter  11 , Nicole Warren-Mora  6
Affiliations
Review

An approach to the identification of anomalies and etiologies in neonates with identified or suspected VACTERL (vertebral defects, anal atresia, tracheo-esophageal fistula with esophageal atresia, cardiac anomalies, renal anomalies, and limb anomalies) association

Benjamin D Solomon et al. J Pediatr. 2014 Mar.
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Examples of findings in VACTERL association. The images in the circles represent radiological examples of findings. Vertebral anomalies: 3-D CT reconstruction showing thoracic segmentation anomalies; Anorectal malformations: contrast imaging showing a rectoprostatic urethral fistula in a patient with an anorectal malformation; Cardiac anomalies: chest x-ray showing a midline heart in a patient with situs anomalies as part of VACTERL association; Tracheo-esophageal anomalies: x-ray showing the position of feeding tube placement (arrow) due to a tracheal pouch; Renal anomalies: axial view from an abdominal CT showing a horseshoe kidney; Limb anomalies: skeletal anomalies affecting the right radius, wrist, and thumb; Examples of other findings: axial view from a brain MRI showing hydrocephalus (due to aqueductal stenosis) Abbreviations: 3-D: three-dimensional; CT: computed tomography; GI: Gastrointestinal
Figure 2
Figure 2
Graphical representation of suggested algorithm for neonates affected with VACTERL association.
See this image and copyright information in PMC

References

    1. Quan L, Smith DW. The VATER association. Vertebral defects, Anal atresia, T-E fistula with esophageal atresia, Radial and Renal dysplasia: a spectrum of associated defects. J Pediatr. 1973;82:104–7. - PubMed
    1. Temtamy SA, Miller JD. Extending the scope of the VATER association: definition of the VATER syndrome. J Pediatr. 1974;85:345–9. - PubMed
    1. Khoury MJ, Cordero JF, Greenberg F, James LM, Erickson JD. A population study of the VACTERL association: evidence for its etiologic heterogeneity. Pediatrics. 1983;71:815–20. - PubMed
    1. Rittler M, Paz JE, Castilla EE. VACTERL association, epidemiologic definition and delineation. Am J Med Genet. 1996;63:529–36. - PubMed
    1. Kallen K, Mastroiacovo P, Castilla EE, Robert E, Kallen B. VATER non-random association of congenital malformations: study based on data from four malformation registers. Am J Med Genet. 2001;101:26–32. - PubMed

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