Key issues in inhibitor management in patients with haemophilia

doi:10.2450/2013.0246-12

Review

. 2014 Jan;12 Suppl 1(Suppl 1):s319-29.

doi: 10.2450/2013.0246-12. Epub 2013 Dec 3.

Key issues in inhibitor management in patients with haemophilia

Keith Gomez¹, Robert Klamroth², Johnny Mahlangu³, Maria E Mancuso⁴, María E Mingot⁵, Margareth Castro Ozelo⁶

Affiliations

¹ Katherine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, London, United Kingdom.
² Department for Internal Medicine, Haemophilia Treatment Centre Vivantes, Klinikum im Friedrichshain, Berlin, Germany.
³ Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa.
⁴ "Angelo Bianchi Bonomi" Haemophilia and Thrombosis Centre, IRCCS Ca' Granda, Ospedale Maggiore Policlinico Foundation, Milan, Italy.
⁵ Haematology Department, Regional University Hospital "Carlos Haya", Málaga, Spain.
⁶ IHTC Haemophilia Unit "Cláudio Luis Pizzigatti Corrêa", INCTS Blood Centre UNICAMP, University of Campinas, São Paulo, Brazil.

PMID: 24333092
PMCID: PMC3934290
DOI: 10.2450/2013.0246-12

Review

Key issues in inhibitor management in patients with haemophilia

Keith Gomez et al. Blood Transfus. 2014 Jan.

. 2014 Jan;12 Suppl 1(Suppl 1):s319-29.

doi: 10.2450/2013.0246-12. Epub 2013 Dec 3.

Authors

Keith Gomez¹, Robert Klamroth², Johnny Mahlangu³, Maria E Mancuso⁴, María E Mingot⁵, Margareth Castro Ozelo⁶

Affiliations

¹ Katherine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, London, United Kingdom.
² Department for Internal Medicine, Haemophilia Treatment Centre Vivantes, Klinikum im Friedrichshain, Berlin, Germany.
³ Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa.
⁴ "Angelo Bianchi Bonomi" Haemophilia and Thrombosis Centre, IRCCS Ca' Granda, Ospedale Maggiore Policlinico Foundation, Milan, Italy.
⁵ Haematology Department, Regional University Hospital "Carlos Haya", Málaga, Spain.
⁶ IHTC Haemophilia Unit "Cláudio Luis Pizzigatti Corrêa", INCTS Blood Centre UNICAMP, University of Campinas, São Paulo, Brazil.

PMID: 24333092
PMCID: PMC3934290
DOI: 10.2450/2013.0246-12

No abstract available

PubMed Disclaimer

Cited by

Expert opinion on the UK standard of care for haemophilia patients with inhibitors: a modified Delphi consensus study.
Khair K, Chalmers E, Flannery T, Griffiths A, Rowley F, Tobaruela G, Chowdary P. Khair K, et al. Ther Adv Hematol. 2021 Apr 30;12:20406207211007058. doi: 10.1177/20406207211007058. eCollection 2021. Ther Adv Hematol. 2021. PMID: 33995986 Free PMC article.
Successful transfemoral prosthesis in a patient with haemophilia A and factor VIII inhibitors: A case report.
Chao TC, Wang SH, Chen YC, Li TY. Chao TC, et al. J Int Med Res. 2023 Aug;51(8):3000605231195446. doi: 10.1177/03000605231195446. J Int Med Res. 2023. PMID: 37646621 Free PMC article.
Risk of Intracranial Hemorrhage in Persons with Hemophilia A in the United States: Real-World Retrospective Cohort Study Using the ATHNdataset.
Hu J, Chandler M, Manuel CM, Caicedo J, Denne M, Ewenstein B, Mokdad AG, Xing S, Recht M. Hu J, et al. J Blood Med. 2024 Apr 24;15:191-205. doi: 10.2147/JBM.S443380. eCollection 2024. J Blood Med. 2024. PMID: 38699197 Free PMC article.
Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A.
Sherman A, Biswas M, Herzog RW. Sherman A, et al. Front Immunol. 2017 Nov 24;8:1604. doi: 10.3389/fimmu.2017.01604. eCollection 2017. Front Immunol. 2017. PMID: 29225598 Free PMC article. Review.
Two-incision laparoscopic appendectomy for a severe hemophilia A child patient with coagulation factor VII deficiency: Case report and review of literature.
He JP, Feng JX. He JP, et al. Medicine (Baltimore). 2017 Oct;96(41):e8197. doi: 10.1097/MD.0000000000008197. Medicine (Baltimore). 2017. PMID: 29019885 Free PMC article.

See all "Cited by" articles

References

1. Bray GL, Gomperts ED, Courter S, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood. 1994;83:2428–35. - PubMed
1. Lusher JM, Arkin S, Abildgaard CF, Schwartz RS. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med. 1993;328:453–9. - PubMed
1. Hay CR, Baglin TP, Collins PW, et al. The diagnosis and management of factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors’ Organization (UKHCDO) Br J Haematol. 2000;111:78–90. - PubMed
1. Lawrence JS, Johnson JB. The presence of a circulating anticoagulant in a male member of a hemophiliac family. Trans Am Clin Climatol Assoc. 1941;57:223–31. - PMC - PubMed
1. Konkle BA, Ebbesen LS, Erhardtsen E, et al. Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. J Thromb Haemost. 2007;5:1904–13. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Bray GL, Gomperts ED, Courter S, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood. 1994;83:2428–35. - PubMed

[2] Bray GL, Gomperts ED, Courter S, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood. 1994;83:2428–35. - PubMed

[3] Lusher JM, Arkin S, Abildgaard CF, Schwartz RS. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med. 1993;328:453–9. - PubMed

[4] Lusher JM, Arkin S, Abildgaard CF, Schwartz RS. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med. 1993;328:453–9. - PubMed

[5] Hay CR, Baglin TP, Collins PW, et al. The diagnosis and management of factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors’ Organization (UKHCDO) Br J Haematol. 2000;111:78–90. - PubMed

[6] Hay CR, Baglin TP, Collins PW, et al. The diagnosis and management of factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors’ Organization (UKHCDO) Br J Haematol. 2000;111:78–90. - PubMed

[7] Lawrence JS, Johnson JB. The presence of a circulating anticoagulant in a male member of a hemophiliac family. Trans Am Clin Climatol Assoc. 1941;57:223–31. - PMC - PubMed

[8] Lawrence JS, Johnson JB. The presence of a circulating anticoagulant in a male member of a hemophiliac family. Trans Am Clin Climatol Assoc. 1941;57:223–31. - PMC - PubMed

[9] Konkle BA, Ebbesen LS, Erhardtsen E, et al. Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. J Thromb Haemost. 2007;5:1904–13. - PubMed

[10] Konkle BA, Ebbesen LS, Erhardtsen E, et al. Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. J Thromb Haemost. 2007;5:1904–13. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Key issues in inhibitor management in patients with haemophilia

Affiliations

Key issues in inhibitor management in patients with haemophilia

Authors

Affiliations

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical