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Review
. 2014 Mar 10;537(2):184-8.
doi: 10.1016/j.gene.2013.11.091. Epub 2013 Dec 10.

Pain assessment in animal models of osteoarthritis

Margaret J Piel  1 , Jeffrey S Kroin  2 , Andre J van Wijnen  3 , Ranjan Kc  4 , Hee-Jeong Im  5
Affiliations
Review

Pain assessment in animal models of osteoarthritis

Margaret J Piel et al. Gene. .

Abstract

Assessment of pain in animal models of osteoarthritis is integral to interpretation of a model's utility in representing the clinical condition, and enabling accurate translational medicine. Here we describe behavioral pain assessments available for small and large experimental osteoarthritic pain animal models.

Keywords: BPI; CBPI; DWB; Dogs; GUVQuest; Glasgow University Veterinary School questionnaire; Guinea pigs; Horses; LABORAS; Lab Animal Behavior Observation Registration and Analysis System; OA; Rabbits; Rodents; basic pain inventory; canine basic pain inventory; dynamic weight bearing; osteoarthritis.

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Conflict of interest statement

Conflict of Interest

The authors declare that there was no actual or potential conflict of interest that could inappropriately influence or be perceived to influence this work.

Figures

Figure 1
Figure 1
The Rotarod Test
Figure 2
Figure 2
Computerized Incapacitance Meter System
Figure 3
Figure 3
Spontaneous photobeam activity system for rearing (vertical photobeam crossings) and ambulatory movement (horizontal photo-beam crossings).
Figure 4
Figure 4
Spontaneous behavior pattern recognition system by LABORAS. Vibration made by animals is measured by ultrasensitive sensors located in two corners of triangular platform
Figure 5
Figure 5
Mechanical allodynia (von Frey filament testing)
Figure 6
Figure 6
Thermal Hyperalgesia
Figure 7
Figure 7
Knee extension
Figure 8
Figure 8
Knee pressure
See this image and copyright information in PMC

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