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Review
. 2014 Mar 28;344(2):180-7.
doi: 10.1016/j.canlet.2013.11.012. Epub 2013 Dec 11.

Cancer stem cells: A contentious hypothesis now moving forward

Michael L O'Connor  1 , Dongxi Xiang  1 , Sarah Shigdar  1 , Joanna Macdonald  1 , Yong Li  2 , Tao Wang  1 , Chunwen Pu  3 , Zhidong Wang  3 , Liang Qiao  4 , Wei Duan  5
Affiliations
Review

Cancer stem cells: A contentious hypothesis now moving forward

Michael L O'Connor et al. Cancer Lett. .

Abstract

Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.

Keywords: Aptamers; Cancer stem cells; Chemoresistance; Clonal evolution; Stemness.

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