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Editorial
. 2014;13(3):335-6.
doi: 10.4161/cc.27507. Epub 2013 Dec 13.

"There will be blood" from fibroblasts

Carlos-Filipe Pereira  1 , Ihor R Lemischka  1 , Kateri Moore  1
Affiliations
Editorial

"There will be blood" from fibroblasts

Carlos-Filipe Pereira et al. Cell Cycle. 2014.
No abstract available

Keywords: Etv6; Gata2; Gfi1b; blood specification; cFos; direct induction; hematopoietic stem cell; hemogenic endothelium; reprogramming.

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Figures

None
Figure 1. Induction of hemogenesis in mouse fibroblasts and perspectives. Gata2, cFos, Gfi1b, and Etv6 were identified as sufficient to induce a hemogenic program in mouse fibroblasts. First, endothelial precursor cells are induced that generate semi-adherent cells with hematopoietic stem cell features. Future perspectives are highlighted including translation to the human system and comparison with hematopoietic stem cell specification during embryogenesis.
See this image and copyright information in PMC

Comment on

  • Induction of a hemogenic program in mouse fibroblasts.
    Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma'ayan A, Schaniel C, Lemischka IR, Moore K. Pereira CF, et al. Cell Stem Cell. 2013 Aug 1;13(2):205-18. doi: 10.1016/j.stem.2013.05.024. Epub 2013 Jun 13. Cell Stem Cell. 2013. PMID: 23770078 Free PMC article.

References

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