Review
doi: 10.1007/BF02935001.
Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes
- PMID: 2433552
- DOI: 10.1007/BF02935001
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Review
Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes
Med Oncol Tumor Pharmacother.
1986.
Abstract
We propose that non-MHC-restricted cytotoxicity is mediated by two distinct types of lymphocyte: NK cells and a unique subset of cytotoxic T-lymphocytes (CTLs). Herein, we review experimental data to support the hypothesis that NK cells and non-MHC-restricted CTLs use different recognition structures and arise from distinct lineages. Furthermore, we demonstrate that non-MHC-restricted CTLs can be generated in vitro by culturing thymocytes in recombinant interleukin-2 (rIL-2).
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