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Review
. 1986;3(3-4):247-54.
doi: 10.1007/BF02935001.

Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes

L L Lanier, J H Phillips
Review

Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes

L L Lanier et al. Med Oncol Tumor Pharmacother. 1986.

Abstract

We propose that non-MHC-restricted cytotoxicity is mediated by two distinct types of lymphocyte: NK cells and a unique subset of cytotoxic T-lymphocytes (CTLs). Herein, we review experimental data to support the hypothesis that NK cells and non-MHC-restricted CTLs use different recognition structures and arise from distinct lineages. Furthermore, we demonstrate that non-MHC-restricted CTLs can be generated in vitro by culturing thymocytes in recombinant interleukin-2 (rIL-2).

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References

    1. Science. 1985 Jun 28;228(4707):1540-3 - PubMed
    1. Cell. 1985 Jan;40(1):183-90 - PubMed
    1. J Exp Med. 1982 Nov 1;156(5):1545-50 - PubMed
    1. J Immunol. 1985 Jul;135(1):672-8 - PubMed
    1. Cytometry. 1984 Mar;5(2):151-8 - PubMed

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