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. 1987 Jan;325(6102):321-6.
doi: 10.1038/325321a0.

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

D E Logothetis, Y Kurachi, J Galper, E J Neer, D E Clapham

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

D E Logothetis et al. Nature. 1987 Jan.

Abstract

Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.

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