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. 2015 Jan;67(1):145-55.
doi: 10.1007/s10616-013-9672-1. Epub 2013 Dec 12.

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Heba S Aboul Ezz  1 , Yasser A Khadrawy, Iman M Mourad
Affiliations

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Heba S Aboul Ezz et al. Cytotechnology. 2015 Jan.

Abstract

Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in industry. Several studies reported that BPA may cause cardiovascular disorders in humans and animals. The present study aims to investigate the effect of BPA on the heart of adult male rats. The rats received a daily oral administration of BPA (25 mg/kg for 6 weeks and 10 mg/kg for 6 and 10 weeks). It was found that BPA at the two studied doses induced a significant increase in malondialdehyde, and a significant decrease in catalase after 6 weeks. Moreover, a significant decrease in reduced glutathione and acetylcholinesterase (AchE) activity was observed after treatment with the two doses of BPA throughout the studied time intervals. The two doses (25 and 10 mg/kg) resulted in a significant decrease in nitric oxide (NO) levels after 6 and 10 weeks, respectively. A significant increase in body weight gain occurred in all animals after BPA treatment. These results suggest that BPA has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of NO and the inhibition of AchE leading to cholinergic activation. The obesity promoting effect of BPA may also participate in the observed cardiovascular disturbances.

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Figures

Fig. 1
Fig. 1
The effect of BPA on malondialdehyde (MDA) and reduced glutathione (GSH) levels and the activities of glutathione-S-transferase (GST) and catalase in the heart of male albino rats. G1 control, G2 BPA-treated (25 mg/kg for 6 weeks), G3 BPA-treated (10 mg/kg for 6 weeks), G4 BPA-treated animals (10 mg/kg for 10 weeks). Asterisk Significant difference with respect to the control, Number sign significant difference with respect to the highest dose (25 mg/kg)
Fig. 2
Fig. 2
The effect of BPA on acetylcholinesterase activity (AchE) and nitric oxide (NO) levels in the heart of male albino rats. G1 control, G2: BPA-treated (25 mg/kg for 6 weeks), G3: BPA-treated (10 mg/kg for 6 weeks), G4: BPA-treated animals (10 mg/kg for 10 weeks). Asterisk Significant difference with respect to the control
Fig. 3
Fig. 3
The effect of BPA on the body weight gain of male albino rats. G1–6W control after 6 weeks, G1–10W control after 10 weeks, G2 BPA-treated (25 mg/kg for 6 weeks), G3 BPA-treated (10 mg/kg for 6 weeks), G4 BPA-treated animals (10 mg/kg for 10 weeks). Asterisk Significant difference with respect to the control
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