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. 2013 Dec 15;591(24):6119-21.
doi: 10.1113/jphysiol.2013.258632.

CrossTalk proposal: Cell volume changes are an essential step in the cell death machinery

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CrossTalk proposal: Cell volume changes are an essential step in the cell death machinery

Florian Lang et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1. Major cell volume regulatory mechanisms in apoptotic cell shrinkage
Osm = organic osmolytes. Dashed arrows indicate inhibition, continuous arrows indicate stimulation of transport system.

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References

    1. Ajiro K, Bortner CD, Westmoreland J, Cidlowski JA. An endogenous calcium-dependent, caspase-independent intranuclear degradation pathway in thymocyte nuclei: antagonism by physiological concentrations of K+ ions. Exp Cell Res. 2008;314:1237–1249. - PMC - PubMed
    1. Bortner CD, Cidlowski JA. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am J Physiol Cell Physiol. 1996;271:C950–C961. - PubMed
    1. Bortner CD, Cidlowski JA. A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol. 1998;56:1549–1559. - PubMed
    1. Bortner CD, Cidlowski JA. Uncoupling cell shrinkage from apoptosis reveals that Na+ influx is required for volume loss during programmed cell death. J Biol Chem. 2003;278:39176–39184. - PubMed
    1. Bortner CD, Cidlowski JA. Cell shrinkage and monovalent cation fluxes: role in apoptosis. Arch Biochem Biophys. 2007;462:176–188. - PMC - PubMed

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