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. 2014 Feb;19(2):153-8.
doi: 10.1111/tmi.12240. Epub 2013 Dec 17.

Dengue epidemics and adverse obstetrical outcomes in French Guiana: a semi-ecological study

Matthieu Hanf  1 , Eleanor Friedman, Celia Basurko, Amaury Roger, Pascal Bruncher, Philippe Dussart, Claude Flamand, Gabriel Carles, Pierre Buekens, Gerard Breart, Bernard Carme, Mathieu Nacher
Affiliations
Free PMC article

Dengue epidemics and adverse obstetrical outcomes in French Guiana: a semi-ecological study

Matthieu Hanf et al. Trop Med Int Health. 2014 Feb.
Free PMC article

Abstract

Objective: To determine whether dengue epidemics are associated with an increase in adverse obstetrical outcomes.

Methods: Semi-ecological study combining individual data on obstetrical events from the perinatal registry and aggregated exposure data from the epidemiologic surveillance of dengue in Cayenne, French Guiana between 2004 and 2007.

Results: After adjustment for individual risk factors, analysis showed that an epidemic level of dengue transmission during the first trimester was associated with an increased risk of post-partum haemorrhage and preterm birth. The associated risks seemed to depend on the epidemic level.

Conclusions: Despite its limitations, this study suggests that dengue in the first trimester may be related to preterm birth and to post-partum bleeding, thus leading to specific hypotheses that should be tested in prospective studies.

Keywords: French Guiana; Post-partum haemorrhage; dengue fever; pregnancy; preterm birth.

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Conflict of interest statement

MH, EF, CB, AR, PB, PD, CF, GC, PB, GB, BC and MN: no conflict

Figures

Figure 1
Figure 1
Monthly confirmed dengue cases (lag 0 and 9 months) and incidence of the 6 studied adverse obstetrical outcomes in the urban area of Cayenne between 2004 and 2007.
See this image and copyright information in PMC

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