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. 2014 Feb;24(2):141-2.
doi: 10.1038/cr.2013.165. Epub 2013 Dec 17.

Regenerative medicine: transdifferentiation in vivo

Lina Fu  1 , Xiping Zhu  1 , Fei Yi  2 , Guang-Hui Liu  3 , Juan Carlos Izpisua Belmonte  4
Affiliations

Regenerative medicine: transdifferentiation in vivo

Lina Fu et al. Cell Res. 2014 Feb.

Abstract

A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.

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