Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011

doi:10.4269/ajtmh.13-0423

. 2014 Feb;90(2):256-9.

doi: 10.4269/ajtmh.13-0423. Epub 2013 Dec 16.

Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011

Shuyi Liang¹, Changjun Bao, Minghao Zhou, Jianli Hu, Fenyang Tang, Xiling Guo, Yongjun Jiao, Wenshuai Zhang, Peilin Luo, Luxun Li, Kuanyuan Zhu, Wenwen Tan, Qimei Lu, Hengming Ge, Abao Chen

Affiliations

Affiliation

¹ School of Public Health, Nanjing Medical University, Nanjing, China; Department of Acute Infectious Diseases Control and Prevention, Institute of Pathogenic Microbiology, and Key Laboratory of Enteric Pathogenic Microbiology, Ministry Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; Xuyi County Center for Disease Control and Prevention, Huaian, China; Lishui County Center for Disease Control and Prevention, Nanjing, China; Jiangning County Center for Disease Control and Prevention, Nanjing, China; Yixing County Center for Disease Control and Prevention, Wuxi, China; Peixian County Center for Disease Control and Prevention, Xuzhou, China; Donghai County Center for Disease Control and Prevention, Lianyungang, China; Liyang County Center for Disease Control and Prevention, Changzhou, China.

PMID: 24343883
PMCID: PMC3919226
DOI: 10.4269/ajtmh.13-0423

Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011

Shuyi Liang et al. Am J Trop Med Hyg. 2014 Feb.

. 2014 Feb;90(2):256-9.

doi: 10.4269/ajtmh.13-0423. Epub 2013 Dec 16.

Authors

Shuyi Liang¹, Changjun Bao, Minghao Zhou, Jianli Hu, Fenyang Tang, Xiling Guo, Yongjun Jiao, Wenshuai Zhang, Peilin Luo, Luxun Li, Kuanyuan Zhu, Wenwen Tan, Qimei Lu, Hengming Ge, Abao Chen

Affiliation

¹ School of Public Health, Nanjing Medical University, Nanjing, China; Department of Acute Infectious Diseases Control and Prevention, Institute of Pathogenic Microbiology, and Key Laboratory of Enteric Pathogenic Microbiology, Ministry Health, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; Xuyi County Center for Disease Control and Prevention, Huaian, China; Lishui County Center for Disease Control and Prevention, Nanjing, China; Jiangning County Center for Disease Control and Prevention, Nanjing, China; Yixing County Center for Disease Control and Prevention, Wuxi, China; Peixian County Center for Disease Control and Prevention, Xuzhou, China; Donghai County Center for Disease Control and Prevention, Lianyungang, China; Liyang County Center for Disease Control and Prevention, Changzhou, China.

PMID: 24343883
PMCID: PMC3919226
DOI: 10.4269/ajtmh.13-0423

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), which is caused by a novel bunyavirus, is an emerging infectious disease in China. In 2011, this new virus was designated as severe fever with thrombocytopenia syndrome virus (SFTSV). The aim of the present study was to determine the seroprevalence and risk factors of SFTSV infection. The investigation was conducted among the general population in Jiangsu Province, China in 2011. A total of 2,510 serum samples were collected. Testing by enzyme-linked immunosorbent assay was conducted to determine the seroprevalence of SFTSV infection. Result showed that the overall seroprevalence of SFTSV infection was 0.44% (11 of 2,510) in seven counties in Jiangsu Province. Multiple variable logistic regression analysis showed that raising goats, farming, and grazing were risk factors for SFTSV infection. Raising goats, farming, and grazing might be important risk factors for virus exposure, and appropriate health education could be useful in preventing infections.

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Figures

**Figure 1.**
Jiangsu Province in China (gray), location of the seven counties (red stars) in Jiangsu Province, and number of participants seropositive for severe fever with thrombocytopenia syndrome in each county.

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References

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[1] Feldmann H. Truly emerging: a new disease caused by a novel virus. N Engl J Med. 2011;364:1561–1563. - PMC - PubMed

[2] Feldmann H. Truly emerging: a new disease caused by a novel virus. N Engl J Med. 2011;364:1561–1563. - PMC - PubMed

[3] Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QL, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Wang Kan B., SW Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song SD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523–1532. - PMC - PubMed

[4] Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QL, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Wang Kan B., SW Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song SD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:1523–1532. - PMC - PubMed

[5] Xu BL, Liu LC, Huang XY, Ma H, Zhang Y, Du Y, Wang P, Tang X, Wang H, Kang K, Zhang S, Zhao G, Wu W, Yang Y, Chen H, Mu F, Chen W. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog. 2011;7:e1002369. - PMC - PubMed

[6] Xu BL, Liu LC, Huang XY, Ma H, Zhang Y, Du Y, Wang P, Tang X, Wang H, Kang K, Zhang S, Zhao G, Wu W, Yang Y, Chen H, Mu F, Chen W. Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog. 2011;7:e1002369. - PMC - PubMed

[7] Chen H, Hu K, Zou J, Xiao J. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis. 2013;17:e206–e208. - PubMed

[8] Chen H, Hu K, Zou J, Xiao J. A cluster of cases of human-to-human transmission caused by severe fever with thrombocytopenia syndrome bunyavirus. Int J Infect Dis. 2013;17:e206–e208. - PubMed

[9] Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu XJ. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis. 2012;18:963–965. - PMC - PubMed

[10] Zhao L, Zhai S, Wen H, Cui F, Chi Y, Wang L, Xue F, Wang Q, Wang Z, Zhang S, Song Y, Du J, Yu XJ. Severe fever with thrombocytopenia syndrome virus, Shandong Province, China. Emerg Infect Dis. 2012;18:963–965. - PMC - PubMed

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Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011

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Seroprevalence and risk factors for severe fever with thrombocytopenia syndrome virus infection in Jiangsu Province, China, 2011

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