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Comparative Study
. 2013 Dec 18:6:540.
doi: 10.1186/1756-0500-6-540.

Haemoglobin A1c: comparing performance of two point of care devices with laboratory analyser

Ruziana Mona Wan Mohd Zin  1 , Zati Iwani Ahmad Kamil, Tuan Rosidah Tuan Soh, Mustaffa Embong, Wan Nazaimoon Wan Mohamud
Affiliations
Comparative Study

Haemoglobin A1c: comparing performance of two point of care devices with laboratory analyser

Ruziana Mona Wan Mohd Zin et al. BMC Res Notes. .

Abstract

Background: Measurement of HbA1c has been widely used for long-term monitoring and management of diabetes control. There is increasing use of point-of-care (POC) devices for measuring HbA1c where quicker results would allow immediate clinical management decisions to be made. Therefore, it is important to evaluate and compare the performance of such devices to the reference laboratory method.

Findings: A total of 274 venous blood was collected from normal healthy adults during the community screening programmes. The performance of POC devices, Afinion and Quo-test were compared to central laboratory HPLC method; Adams A1c HA 8160. Both POC devices showed good correlation to HA 8160 with r = 0.94 (p < 0.001) and r = 0.95 (p < 0.001) for Afinion and Quo-test respectively. The means difference were statistically higher between POC and HA 8160 with 0.23% (95% CI 0.19-0.26, p < 0.001) and 0.29% (95% CI 0.24-0.34, p < 0.001) for Afinion and Quo-test respectively.

Conclusions: Both POC devices could be considered in health clinics for diabetes management but not to be used for the diagnostic purposes.

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Figures

Figure 1
Figure 1
Method correlation of (A) Afinion and (B) Quo-test compared with HA8160. The solid line indicates the linear regression whereas the dashed line indicates 95% confidence interval.
Figure 2
Figure 2
Bland Altman difference plots of (A) Afinion and (B) Quo-test compared with HA8160. The solid line indicates the mean difference whereas the dashed lines indicate upper and lower limit of agreement.
See this image and copyright information in PMC

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