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Review
. 2014 Jan;141(1):5-9.
doi: 10.1242/dev.094805.

Sphingosine 1-phosphate signalling

Karen Mendelson  1 , Todd Evans, Timothy Hla
Affiliations
Review

Sphingosine 1-phosphate signalling

Karen Mendelson et al. Development. 2014 Jan.

Abstract

Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.

Keywords: S1P receptors; Sphingomyelin; Sphingosine-1-phosphate.

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