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Review
. 2013 Nov-Dec;88(6 Suppl 1):197-9.
doi: 10.1590/abd1806-4841.20132588.

Systemic sarcoidosis induced by etanercept: first Brazilian case report

Natasha Unterstell  1 , Aline Lopes Bressan  2 , Laura Araújo Serpa  1 , Pérola Peres da Fonseca e Castro  1 , Alexandre Carlos Gripp  2
Affiliations
Review

Systemic sarcoidosis induced by etanercept: first Brazilian case report

Natasha Unterstell et al. An Bras Dermatol. 2013 Nov-Dec.

Abstract
in English, Portuguese

The antagonists of tumor necrosis factor alpha (TNF-α) are increasingly being used in the treatment of inflammatory and autoimmune diseases. Several adverse effects of these drugs have been reported, including the paradoxical development of sarcoidosis, especially with the use of etanercept. We present the first Brazilian case report of systemic sarcoidosis induced by etanercept and a literature review.

Os medicamentos antagonistas do fator de necrose tumoral alfa (TNF-α) estão sendo cada vez mais utilizados no tratamento de doenças inflamatórias e autoimunes. Efeitos adversos desses medicamentos vem sendo relatados, incluindo o desenvolvimento paradoxal de sarcoidose, principalmente com o uso do etanercepte. Apresentamos o primeiro relato de caso brasileiro de sarcoidose sistêmica induzida por etanercepte e uma revisão da literatura.

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Conflict of interest statement

Conflict of interest: None

Figures

FIGURE 1
FIGURE 1
Erythematous, infiltrated lesions surrounding a cicatricial area on the posterior region of the right thigh
FIGURE 2
FIGURE 2
Erythema nodosum on lower limbs
FIGURE 3
FIGURE 3
Thoracic CT scan showing perihilar pulmonary lymphadenomegaly
FIGURE 4
FIGURE 4
Histopathological exam (100x zoom) of the right thigh lesion showing well-delimitated, noncaseating granulomas in the dermis and hypodermis
FIGURE 5
FIGURE 5
Histopathological exam (1000x zoom): noncaseating granuloma formed by histiocytes and giant cells
See this image and copyright information in PMC

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References

    1. Daldon PEC, Arruda LHF. Noninfectious granulomas: sarcoidosis. An Bras Dermatol. 2007;82:559–571.
    1. Aguiar M, Marçal N, Mendes AC, Bugalho de Almeida A. Infliximab for treating sarcoidosis patients, Portuguese experience. Rev Port Pneumol. 2011;17:85–93. - PubMed
    1. Hostettler KE, Studler U, Tamm M, Brutsche MH. Long-term treatment with infliximab in patients with sarcoidosis. Respiration. 2012;83:218–224. - PubMed
    1. Gifre L, Ruiz-Esquide V, Xaubet A, Gómez-Puerta JA, Hernández MV, Sanmartí R. Lung sarcoidosis induced by TNF antagonists in rheumatoid arthritis: a case presentation and a literature review. Arch Bronconeumol. 2011;47:208–212. - PubMed
    1. Fok KC, Ng WW, Henderson CJ, Connor SJ. Cutaneous sarcoidosis in a patient with ulcerative colitis on infliximab. J Crohns Colitis. 2012;6:708–712. - PubMed

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