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Review
. 2014 Apr;57(4):224-30.
doi: 10.1002/jlcr.3165. Epub 2013 Dec 18.

Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals

Zhengxin Cai  1 , Carolyn J Anderson
Affiliations
Review

Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals

Zhengxin Cai et al. J Labelled Comp Radiopharm. 2014 Apr.

Abstract

The development of chelating agents for copper radionuclides in positron emission tomography radiopharmaceuticals has been a highly active and important area of study in recent years. The rapid evolution of chelators has resulted in highly specific copper chelators that can be readily conjugated to biomolecules and efficiently radiolabeled to form stable complexes in vivo. Chelators are not only designed for conjugation to monovalent biomolecules but also for incorporation into multivalent targeting ligands such as theranostic nanoparticles. These advancements have strengthened the role of copper radionuclides in the fields of nuclear medicine and molecular imaging. This review emphasizes developments of new copper chelators that have most greatly advanced the field of copper-based radiopharmaceuticals over the past 5 years.

Keywords: PET; chelator; copper 64; molecular imaging; radiopharmaceutical.

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Conflict of interest statement

Conflict of Interest

The authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Examples of acyclic chelators.
Figure 2
Figure 2
Examples of nonbridged macrocyclic chelators.
Figure 3
Figure 3
Examples of cross-bridged macrocyclic chelators.
Figure 4
Figure 4
Examples of sarcophagine-based chelators.
Figure 5
Figure 5
Examples of clickable chelators.
Figure 6
Figure 6
Examples of strain-promoted clickable chelators.
See this image and copyright information in PMC

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References

    1. James ML, Gambhir SS. Physiol Rev. 2012;92:897. - PubMed
    1. Gillings N. Magn Reson Mater Phys, Biol Med. 2013;26:149.
    1. Bartholomä MD. Inorg Chim Acta. 2012;389:36.
    1. Wadas TJ, Wong EH, Weisman GR, Anderson CJ. Chem Rev. 2010;110:2858. - PMC - PubMed
    1. Coles MP. Annu Rep Prog Chem, Sect A: Inorg Chem. 2012;108:220.

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