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Comment
. 2013 Dec;10(12):e1001565.
doi: 10.1371/journal.pmed.1001565. Epub 2013 Dec 3.

Artemisinin combination therapy: a good antimalarial, but is the dose right?

Paul Garner  1
Affiliations
Comment

Artemisinin combination therapy: a good antimalarial, but is the dose right?

Paul Garner. PLoS Med. 2013 Dec.

Abstract

In an accompanying Perspective, Paul Garner further discusses dosing issues for artemisinin combination therapy.

Please see later in the article for the Editors' Summary

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Conflict of interest statement

The author is Director of Evidence Building and Synthesis Research Consortium, which receives money to increase the number of evidence-informed decisions by intermediary organizations, including WHO and national decision makers that benefit the poor in middle- and low-income countries. The author is the coordinator of a WHO Collaborating Centre for Evidence Synthesis for Infectious and Tropical Diseases (http://apps.who.int/whocc/default.aspx; UNK234). One of the Centre's aims is to help WHO in its role as an infomediary in communicating reliable summaries of research evidence to policymakers, clinicians, teachers, and the public in developing countries. Technical advice was sought from Dr. Dianne J. Terlouw on the pharmacokinetic background to these drugs. Dr. Terlouw is the Principal Investigator on a trial examining dose optimisation with DHAP. Dr. Terlouw had no part in writing the manuscript and the views expressed are entirely those of the author.

Comment on

References

    1. International Artemisinin Study Group (2004) Artesunate combinations for treatment of malaria: meta-analysis. Lancet 363: 9–17. - PubMed
    1. World Health Organization (2006) Guidelines for the treatment of malaria, first edition. Geneva: World Health Organization.
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    1. World Health Organization (2010) Guidelines for the treatment of malaria, second edition. Geneva: World Health Organization. Available: http://whqlibdoc.who.int/publications/2010/9789241547925_eng.pdf. Accessed: 14 OCTOBER 2013.
    1. White NJ (2013) Pharmacokinetic and pharmacodynamics considerations in antimalarial dose optimization. Antimicrob Agents Chemother Epub ahead of print 3 September 2013. doi:–10.1128/AAC.00287–13 - DOI - PMC - PubMed

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