doi: 10.1128/mcb.7.2.946-950.1987.
Polyomavirus middle T antigen downregulates junctional cell-to-cell communication
- PMID: 2434836
- PMCID: PMC365156
- DOI: 10.1128/mcb.7.2.946-950.1987
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Polyomavirus middle T antigen downregulates junctional cell-to-cell communication
Mol Cell Biol.
1987 Feb.
Abstract
We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.
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