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Review
. 2013 Dec 2:4:195.
doi: 10.3389/fneur.2013.00195.

Neurobehavioral effects of levetiracetam in patients with traumatic brain injury

Jared F Benge  1 , Richard A Phenis  1 , Abigail Bernett  1 , Daniel Cruz-Laureano  1 , Batool F Kirmani  1
Affiliations
Review

Neurobehavioral effects of levetiracetam in patients with traumatic brain injury

Jared F Benge et al. Front Neurol. .

Abstract

Moderate to severe traumatic brain injury (TBI) is one of the leading causes of acquired epilepsy. Prophylaxis for seizures is the standard of care for individuals with moderate to severe injuries at risk for developing seizures, though relatively limited comparative data is available to guide clinicians in their choice of agents. There have however been experimental studies which demonstrate potential neuroprotective qualities of levetiracetam after TBI, and in turn there is hope that eventually such agents may improve neurobehavioral outcomes post-TBI. This mini-review summarizes the available studies and suggests areas for future studies.

Keywords: levetiracetam; neurobehavioral effects; neurobehavioral outcomes; neurological functioning; traumatic brain injury.

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References

    1. Faul M, Xu L, Wald MM, Coronado VG. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations, and Deaths. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; (2010).
    1. Rohling ML, Meyers JE, Millis SR. Neuropsychological impairment following traumatic brain injury: a dose-response analysis. Clin Neuropsychol (2003) 17:289–302 10.1076/clin.17.3.289.18086 - DOI - PubMed
    1. Dikmen S, Machamer J, Temkin N, McLean A. Neuropsychological recovery in patients with moderate to severe head injury: 2 year follow-up. J Clin Exp Neuropsychol (1989) 12:507–19 10.1080/01688639008400997 - DOI - PubMed
    1. Roebuck-Spencer T, Sherer M. Moderate and severe traumatic brain injury. In: Morgan J, Richker H. editors. Textbook of Clinical Neuropsychology. New York, NY: Taylor and Francis; (2008). p. 411–29
    1. Temkin NR. Preventing and treating posttraumatic seizures: the human experience. Epilepsia (2009) 50:10–3 10.1111/j.1528-1167.2008.02005.x - DOI - PubMed

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