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. 2013 Nov 20;3(1):118-124.
doi: 10.1159/000356464. eCollection 2013.

Impact of Growth Hormone on Cystatin C

Lisa Sze  1 , René L Bernays  2 , Cornelia Zwimpfer  3 , Peter Wiesli  4 , Michael Brändle  3 , Christoph Schmid  3
Affiliations

Impact of Growth Hormone on Cystatin C

Lisa Sze et al. Nephron Extra. .

Abstract

Background: Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of growth hormone (GH) on CysC in patients with acromegaly undergoing transsphenoidal surgery.

Methods: Creatinine, CysC, GH and insulin-like growth factor-1 (IGF-1) were determined in 24 patients with acromegaly before and following transsphenoidal surgery. Estimated GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.

Results: In all patients, surgical debulking resulted in decreased clinical disease activity and declining GH/IGF-1 levels. Postoperatively, biochemical cure was documented in 20 out of 24 patients. Creatinine levels (mean ± SEM) increased from 72 ± 3 to 80 ± 3 µmol/l (p = 0.0004) and concurrently, estimated GFR decreased from 99 ± 3 to 91 ± 3 ml/min (p = 0.0008). In contrast to creatinine, CysC levels decreased from 0.72 ± 0.02 to 0.68 ± 0.02 mg/l (p = 0.0008).

Conclusions: Our study provides strong evidence for discordant effects of GH on creatinine and CysC in patients with acromegaly undergoing transsphenoidal surgery, thus identifying another hormone that influences CysC independent of renal function.

Keywords: Acromegaly; Creatinine; Cystatin C; Growth hormone; Kidney.

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Figures

Fig. 1
Fig. 1
Creatinine (a) (p = 0.0004) and CysC (b) (p = 0.0008) before and after surgery. Males = Circles, solid lines; females = triangles, dashed lines.
See this image and copyright information in PMC

References

    1. Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367:20–29. - PMC - PubMed
    1. Randers E, Kristensen JH, Erlandsen EJ, Danielsen H. Serum cystatin C as a marker of the renal function. Scand J Clin Lab Invest. 1998;58:585–592. - PubMed
    1. Stevens LA, Schmid CH, Greene T, et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75:652–660. - PMC - PubMed
    1. Weinert LS, Prates AB, do Amaral FB, Vaccaro MZ, Camargo JL, Silveiro SP. Gender does not influence cystatin C concentrations in healthy volunteers. Clin Chem Lab Med. 2010;48:405–408. - PubMed
    1. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40:221–226. - PubMed