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. 2013:2013:145925.
doi: 10.1155/2013/145925. Epub 2013 Nov 14.

Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

Chandrasekaran Chinampudur Velusami  1 , Amit Agarwal  2 , Vijayalakshmi Mookambeswaran  3
Affiliations

Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity

Chandrasekaran Chinampudur Velusami et al. Evid Based Complement Alternat Med. 2013.

Abstract

N. nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models. The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N. nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors. Both methanol and successive water extracts of N. nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis. N. nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC50 value of 47 µg/mL. N. nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively, while it showed no effect towards MCHR1 and MC4R receptors. Overall, methanol extract of N. nucifera petals showed better activity than successive water extract.

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Figures

Figure 1
Figure 1
Effect of N. nucifera on adipogenesis using 3T3-L1 cells.
Figure 2
Figure 2
Effect of N. nucifera on glycerol release from differentiated 3T3-L1 cells.
See this image and copyright information in PMC

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