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. 2014 Jan;7(1):3-7.
doi: 10.3892/etm.2013.1374. Epub 2013 Oct 30.

Human papillomavirus oncoproteins and apoptosis (Review)

Peiyue Jiang  1 , Ying Yue  1
Affiliations

Human papillomavirus oncoproteins and apoptosis (Review)

Peiyue Jiang et al. Exp Ther Med. 2014 Jan.

Abstract

The aim of this study was to review the literature and identify the association between human papillomavirus (HPV) oncoproteins and apoptosis. HPV-associated apoptosis may be primarily blocked by a number of oncoproteins, including E5, E6 and E7. E5 protein protects cells from tumor necrosis factor-associated apoptosis; the oncoprotein E6 predominantly inhibits apoptosis through the p53 pathway; and oncoprotein E7 is involved in apoptosis activation and inhibition. In addition, HPV oncoproteins are involved in activating or repressing the transcription of E6/E7. In conclusion, HPV oncoproteins, including E5, E6 and E7 protein, may interfere with apoptosis via certain regulatory principles.

Keywords: apoptosis; human papillomavirus; incorporation; oncoprotein.

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Figures

Figure 1
Figure 1
Modulation of apoptosis by HPV early proteins: A number of the interactions of viral oncoproteins with cellular proteins and their effects on apoptosis. E2 protein is able to induce apoptosis by downregulating the transcription of E6/E7 mRNA and by binding with p53, respectively. E5 impairs the formation of the death-inducing signaling complex triggered by FasL and TRAIL. E6 protein inhibits apoptosis by targeting proapoptotic proteins, including p53 and Bax, for proteolytic degradation. E6 protein also protects cells from death receptor-induced apoptosis by blocking apoptotic signal transduction and inducing the expression of IAPs. E7 oncoprotein-expressing cells are usually predisposed to undergo apoptosis, in part due to degradation of the antiapoptotic protein pRb and E2F-1 binding. Downwards arrow, degradation of cellular proteins; inhibition arrow, inhibition status of the pathway; upwards arrow, upregulation of proteins. HPV, human papillomavirus; FasL, Fas ligand; TNF, tumor necrosis factor; TRAIL, TNF-related apoptosis-inducing ligand; IAP, inhibitor of apoptosis; TNFR, TNF receptor; FADD, Fas-associated protein with death domain.
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References

    1. Nichols AC, Palma DA, Chow W, et al. High frequency of activating PIK3CA mutations in human papillomavirus-positive orpharyngeal cancer. JAMA Otolaryngol Head Neck Surg. 2013;139:617–622. - PubMed
    1. Yuan CH, Filippova M, Duerksen-Hughes P. Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Viruses. 2012;4:3831–3850. - PMC - PubMed
    1. Kaspersen MD, Larsen PB, Ingerslev HJ, et al. Identification of multiple HPV types on spermatozoa from human sperm donors. PLoS One. 2011;6:e18095. - PMC - PubMed
    1. Schlecht NF, Kulaga S, Robitaille J, et al. Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA. 2001;286:3106–3114. - PubMed
    1. Alam MS, Ali A, Mehdi SJ, et al. HPV typing and its relation with apoptosis in cervical carcinoma from Indian population. Tumor Biol. 2012;33:17–22. - PubMed

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