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Clinical Trial
. 2013 Dec 11;8(12):e81597.
doi: 10.1371/journal.pone.0081597. eCollection 2013.

Association of ideal cardiovascular metrics and serum high-sensitivity C-reactive protein in hypertensive population

Hao Xue  1 , Jianli Wang  2 , Jinhong Hou  2 , Hang Zhu  1 , Jingsheng Gao  2 , Shuohua Chen  2 , Yutang Wang  1 , Yundai Chen  1 , Shouling Wu  2
Affiliations
Clinical Trial

Association of ideal cardiovascular metrics and serum high-sensitivity C-reactive protein in hypertensive population

Hao Xue et al. PLoS One. .

Abstract

Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk of cardiovascular disease. However, ideal cardiovascular health indicates lower risk of cardiovascular disease. This study aimed to investigate the effect of ideal cardiovascular health behaviors and health factors on hs-CRP levels among a hypertensive population. From 2006 to 2007, a cross-sectional study was conducted to survey 41,476 hypertensive subjects among the employees of Kailuan Corporation. Data from unified questionnaires and blood biochemical examinations were collected. The effects of ideal cardiovascular health behaviors and health factors on hs-CRP levels were evaluated through multivariate logistic regression analysis. A negative correlation was observed between hs-CRP levels and the number of ideal cardiovascular health metrics. The mean hs-CRP levels of subjects with zero to one, two, three, and four to six ideal cardiovascular health metrics were 1.11, 0.96, 0.90, and 0.80 mg/L, respectively (P<0.01). Multivariate logistic regression analysis revealed that after adjustment for sex, age, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and other risk factors, the risks for subjects with two, three, and four to six ideal health metrics with serum hs-CRP >3 mg/L were lower than those with zero to one ideal health metrics, with corresponding odd ratios of 0.86 (95%CI: 0.79-0.93, P<0.01), 0.76 (95%CI: 0.69-0.83, P<0.01), and 0.68 (95%CI: 0.64-0.75, P<0.01), respectively. This finding suggests that ideal cardiovascular health behaviors and health factors were related to decreased hs-CRP levels in a hypertensive population.

Clinical trial registration: UNIQUE IDENTIFIER: ChiCTR-TNC-11001489.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Serum hs-CRP indifferent groups of Ideal Cardiovascular Health Metrics in the hypertensive population, different genders hypertensive population.
The hs-CRP levels are presented as box (median, 25th percentile, 75th percentile) and whisker (2.5th and 97.5th percentiles) plots.
See this image and copyright information in PMC

References

    1. Ministry of health of the people’s Republic of China (2010) China Health Statistics Yearbook [M]. Peking Union Medical College press. 276: 315.
    1. Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, et al. (2010) Defining and setting national goal for cardiovascular health promotion and disease reduction: The American heart association’s strategic impact gola through 2020 and beyond. Circulation 121: 586–613. - PubMed
    1. Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, et al. (2012) Does high-sensitivity C-reactive protein or low-density lipoprotein cholesterol show a stronger relationship with the cardio-ankle vascular index in healthy community dwellers?: the KOBE study. J Atheroscler Thromb 19: 1027–34. - PubMed
    1. Shafi Dar M, Pandith AA, Sameer AS, Sultan M, Yousuf A, et al. (2010) hs-CRP: A potential marker for hypertension in Kashmiri population. Indian J Clin Biochem 25: 208–12. - PMC - PubMed
    1. Marques-Vidal P, Bochud M, Bastardot F, Lüscher T, Ferrero F, et al. (2012) Association between inflammatory and obesity markers in a Swiss population-based sample (CoLaus Study). Obes Facts 5: 734–44. - PubMed

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