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Meta-Analysis
. 2013 Dec 9;8(12):e82465.
doi: 10.1371/journal.pone.0082465. eCollection 2013.

The A930G polymorphism ofP22phox (CYBA) gene but not C242T variation is associated with hypertension: a meta-analysis

Yu-Wang Qin  1 , Jiao Peng  2 , Bao-Yun Liang  1 , Li Su  3 , Qing Chen  1 , Juan-Juan Xie  1 , Lian Gu  1
Affiliations
Meta-Analysis

The A930G polymorphism ofP22phox (CYBA) gene but not C242T variation is associated with hypertension: a meta-analysis

Yu-Wang Qin et al. PLoS One. .

Abstract

Background: Recently, it has been reported that the A930G and C242T polymorphisms within p22phox (CYBA) gene are involved in the pathogenesis of hypertension. However, the results remain controversial. Furthermore, no previous meta-analysis has been conducted to evaluate the relationship between the A930G and C242T polymorphisms and hypertension. Therefore, we performed this meta-analysis to clarify these controversies.

Objective and methods: All of the included articles were retrieved from the PubMed and Embase databases, as well as the CNKI, CBM, Chongqing VIP and Wan Fang databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were used to assess the strength of the association. Accounting for heterogeneity, a fixed or random effects model was respectively adopted. Heterogeneity was checked using the Q test and the I(2) statistic. A cumulative meta-analysis was conducted to estimate the tendency of pooled OR. Funnel plots and Egger's tests were performed to test for possible publication bias.

Results: Five articles on A930G with 2003 cases/2434 controls and eight articles on C242T with 2644 cases/1967 controls were identified. A significant association of A930G polymorphisms with the risk of hypertension was found in the dominant model (OR=0.59, 95% CI: 0.38-0.92, p=0.021) and allelic model (OR=0.66, 95% CI: 0.46-0.95, p=0.024). In the stratified analysis, a significant association could be found among the hospital-based and population-based studies. However, no evidence of a significant association of the C242T polymorphism with hypertension was found in the overall analysis and subgroup analysis.

Conclusions: This meta-analysis indicates that the A930G polymorphism, but not the C242T variation, might be a protective factor for hypertension.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart of the articles selection for associations of the A930G/C242T polymorphism with hypertension.
(Follow the PRISMA guidelines).
Figure 2
Figure 2. Forest plots of hypertension associated with the CYBA A930G polymorphism.
Figure 3
Figure 3. Forest plots for the association of the CYBA A930G polymorphism in the stratified analysis for source of controls.
Figure 4
Figure 4. Forest plots of hypertension associated with the CYBA C242T polymorphism.
Figure 5
Figure 5. Cumulative plot of the association between the CYBA C242T polymorphism and hypertension for the dominate model chronologically.
See this image and copyright information in PMC

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