Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:901246.
doi: 10.1155/2013/901246. Epub 2013 Nov 18.

Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis

Nadia Innaro  1 , Elena Succurro  2 , Giuseppe Tomaino  1 , Franco Arturi  2
Affiliations

Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis

Nadia Innaro et al. Case Rep Oncol Med. 2013.

Abstract

Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Proliferation of cellular elements with epithelial appearance, with large vesicular nucleus, and with prominent nucleolus. (b) Areas consist of irregular spaces containing material blood bordered by atypical cells with intraluminal papillary projections.
Figure 2
Figure 2
(a) Angiosarcoma cells show positivity for CD31 antigen (monoclonal mouse clone JC70A—Dako—40x). (b) Factor VIII-related antigen positivity in the angiosarcoma cells (policlonal rabbit—DAKO—40x). (c) Tumor cells express partially pancytokeratin (CK-) related antigen (cytokeratin monoclonal mouse clone AE1/AE3—DAKO—40x).
See this image and copyright information in PMC

References

    1. Chan YF, Ma L, Boey JH, Yeung HY. Angiosarcoma of the thyroid. An immunohistochemical and ultrastructural study of a case in a Chinese patient. Cancer. 1986;57(12):2381–2388. - PubMed
    1. Ryška A, Ludvíková M, Szépe P, Böör A. Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non-Alpine region. Histopathology. 2004;44(1):40–46. - PubMed
    1. Yilmazlar T, Kirdak T, Adim S, Ozturk E, Yerci O. A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis. Endocrine Journal. 2005;52(1):57–59. - PubMed
    1. Bandorski D, Arps H, Jaspersen D, Diehl KL. Severe intestinal bleeding caused by intestinal metastases of a primary angiosarcoma of the thyroid gland. Zeitschrift fur Gastroenterologie. 2002;40(9):811–814. - PubMed
    1. Rhomberg W, Böhler F-K, Eiter H, Fritzsche H, Breitfellner G. Malignant hemangioendothelioma of the thyroid. New results related to pathogenesis, treatment, and prognosis. Wiener Klinische Wochenschrift. 1998;110(13-14):479–484. - PubMed

LinkOut - more resources