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. 2013 Oct;4(4):288-91.
doi: 10.4103/2229-5178.120639.

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Mary Thomas  1 , Uday Sharadchandra Khopkar  1
Affiliations

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Mary Thomas et al. Indian Dermatol Online J. 2013 Oct.

Abstract

Context: Necrobiosis lipoidica (NL) is a chronic granulomatous dermatitis that is commonly associated with diabetes mellitus. Most of the current knowledge about this entity is from western literature.

Aims: This study evaluates the clinicohistological features of NL in an Indian scenario.

Materials and methods: We retrospectively reviewed clinical features, associated comorbidities, and biopsies of all patients with NL over a period of one year.

Results: Five cases of NL were seen during the duration of the study. The preliminary clinical diagnosis ranged from sarcoidosis to tinea incognito. The commonest clinical presentation in the Indian scenario was of asymptomatic erythematous to skin-colored plaques and nodules on the shins with or without central atrophy. The most common site of involvement was the shin (3 of 5 patients). NL was associated with Diabetes mellitus in only two cases, both of whom were male patients. On histology, various patterns of inflammation were seen including the palisading, interstitial, and mixed granulomatous infiltrates. One patient had sarcoidal granulomas in association with an interstitial pattern. Features seen consistently in all cases include perivascular lymphoplasmacytic infiltrates, interstitial lymphocytic infiltrates, and fibroplasia. Interstitial mucin deposition was not observed in any of the biopsies.

Conclusion: The diagnosis of NL was missed in most cases due to the rarity of the disease, absence of concomitant diabetes, and atypical presentations. Histology was a useful tool in clinching the diagnosis.

Keywords: Diabetes; necrobiosis lipoidica; palisading granuloma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Necrobiosis Lipoidica in Indian Skin: asymptomatic erythematous to brown-colored plaques with central atrophy
Figure 2
Figure 2
Classical Necrobiosis Lipoidica: yellowish brown plaque with a peripheral violaceous hue
Figure 3
Figure 3
Palisading granulomas in a tired/wedding cake appearance [H and E, ×4]
Figure 4
Figure 4
Mixed (palisading +interstitial) infiltrate in Necrobiosis Lipoidica [H and E, ×4]
See this image and copyright information in PMC

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