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Case Reports
. 2013 Oct;4(4):347-9.
doi: 10.4103/2229-5178.120680.

Progressive symmetric erythrokeratoderma with nephrotic syndrome: Coincidence or new association?

S Sacchidanand  1 , M S Sahana  1 , Sushruth G Kamoji  1 , G S Asha  1
Affiliations
Case Reports

Progressive symmetric erythrokeratoderma with nephrotic syndrome: Coincidence or new association?

S Sacchidanand et al. Indian Dermatol Online J. 2013 Oct.

Abstract

Progressive symmetric erythrokeratoderma (PSEK) is a rare genodermatosis with variable inheritance. It is characterized by symmetrical, erythematous, and hyperkeratotic plaques on the extremities. We report a case of a 15-year-old boy with PSEK of autosomal recessive inheritance associated with nephrotic syndrome.

Keywords: Erythrokeratoderma; nephrotic syndrome; symmetric.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Well-demarcated hyperkeratotic plaques on dorsum of hands
Figure 2
Figure 2
Well-demarcated symmetrical hyperkeratotic plaques on dorsum of feet and lower legs
Figure 3
Figure 3
Well-demarcated symmetrical hyperpigmented, hyperkeratotic plaques on knee joint and dorsum of feet
Figure 4
Figure 4
Moderate acanthosis, hyperkeratosis, focal parakeratosis, and mild superficial perivascular dermal lymphocytic infiltrate (H and E, ×400)
See this image and copyright information in PMC

References

    1. Walia NS, Raj R, Tak CS. Gottron's syndrome. Indian J Dermatol Venereol Leprol. 2001;67:211. - PubMed
    1. van Steensel MA, van Geel M, Nahuys M, Smitt JH, Steijlen PM. A novel connexin 26 mutation in a patient diagnosed with keratitis-ichthyosis-deafness syndrome. J Invest Dermatol. 2002;118:724–7. - PubMed
    1. Bongiorno MR, Aricò M. Progressive symmetric erythrokeratodermia associated with oligodontia, severe caries, disturbed hair growth and ectopic nail: A new syndrome? Dermatology. 2008;217:347–50. - PubMed
    1. Gottron HA. Congenital symmetrical progressive erythrokeratoderma. Arch Dermatol Syph. 1923;7:416.
    1. Yan H, Zhang J, Liang W, Zhang H, Liu J. Progressive symmetric erythrokeratoderma: Report of a Chinese family. Indian J Dermatol Venereol Leprol. 2011;77:597–600. - PubMed

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