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. 2013 Oct;3(4):188-93.
doi: 10.4103/2230-973X.121289.

Teucrium polium L. extract adsorbed on zinc oxide nanoparticles as a fortified sunscreen

Mehdi Ansari  1 , Fariba Sharififar  2 , Maryam Kazemipour  3 , Zarrin Sarhadinejad  1 , Hamid Mahdavi  4
Affiliations

Teucrium polium L. extract adsorbed on zinc oxide nanoparticles as a fortified sunscreen

Mehdi Ansari et al. Int J Pharm Investig. 2013 Oct.

Abstract

Introduction: Zinc oxide nanoparticles (ZnOn) have been used as carriers and sun-protecting agents for Teucrium polium L. extract to enhance sun protection. ZnOn was synthesized by hydrolyzing zinc acetate using sodium hydroxide with mean particle diameter less than 500 nm.

Materials and methods: Top flowerings of T. polium L. were extracted by percolation method with petroleum ether, chloroform, and 80% methanol consecutively. Methanolic extract was lyophilized and used as a flavonoid-rich fraction. Sunscreen was prepared by the reconstitution of 0.5 g of the lyophilized extract in water and mixing with 0.5 to 2 g zinc-oxide (ZnO). Sun protection factor (SPF) of the aqueous extract of T. polium, the prepared gel, as well as the zinc oxide suspension alone and in combination with each other was determined spectrophotometrically based on a modified Transpore(®) tape method.

Results and conclusion: Obtained results showed that the T. polium extract has a wide band of ultraviolet radiation (UV) spectrum absorption ranging from 250 nm to 380 nm. SPF of the combination product in the ultraviolet B (UVB) area was greater than 80, revealing a synergistic action between ZnO and T. polium. The adsorption of flavonoids of T. polium on Zinc-oxide nanoparticles (ZnOn) slowed down their release thereby lengthening their persistence on the skin and contributing to further duration of action.

Keywords: Nanomedicines; Sun protection factor; Teucrium polium.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
UV spectrum of T. polium methanolic extract (0.1 mg/ml) (a) extract before addition of ZnOn (b) extract after addition of ZnOn
Figure 2
Figure 2
UV spectrum of prepared formulation (a) without PEG and (b) with PEG 400
Figure 3
Figure 3
SEM image of ZnO nanoparticles
Figure 4
Figure 4
UV spectrum of different concentrations of methanolic extract of T. polium (40, 60, 80, 100, and 120 mg/l)
Figure 5
Figure 5
Release profile of T. polium methanolic extract on the basis of rutin from formulation No 11
See this image and copyright information in PMC

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References

    1. Lautenschlager S, Wulf HC, Pittelkow MR. Photoprotection. Lancet. 2007;370:528–37. - PubMed
    1. Gordon M. Dietary antioxidants in disease prevention. Nat Prod Rep. 1996;13:265–73. - PubMed
    1. Yener G, Incegül T, Yener N. Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate. Int J Pharm. 2003;258:203–7. - PubMed
    1. Ngo MA, Maibach HI. Dermatotoxicology: Historical perspective and advances. Toxicol Appl Pharmacol. 2010;243:225–38. - PubMed
    1. Watkinson AC, Brain KR, Walters KA, Hadgraft J. Prediction of the percutaneous penetration of ultra-violet filters used in sunscreen formulations. Int J Cosmet Sci. 1992;14:265–75. - PubMed