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Editorial
. 2014 Feb;13(2):185-8.
doi: 10.1586/14760584.2014.870888. Epub 2013 Dec 18.

Live attenuated vaccine: the first clinically approved dengue vaccine?

Katja Fink  1 , Pei-Yong Shi
Affiliations
Editorial

Live attenuated vaccine: the first clinically approved dengue vaccine?

Katja Fink et al. Expert Rev Vaccines. 2014 Feb.

Abstract

Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. There are 390 million human infections each year, with 96 million infections exhibiting disease symptoms. Currently, there is no clinically approved vaccine and antiviral for DENV. The four serotypes of DENV (DENV-1, -2, -3 and -4) have 25-40% variation at the amino acid level. Such variation has posed challenges for the development of a tetravalent vaccine and therapeutics.

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