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Review
. 2014 Feb;59(2):110-5.
doi: 10.1038/jhg.2013.130. Epub 2013 Dec 19.

Confounding by linkage disequilibrium

Brahim Aissani  1
Affiliations
Free PMC article
Review

Confounding by linkage disequilibrium

Brahim Aissani. J Hum Genet. 2014 Feb.
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
Colocalization of human traits of potential relevance to uterine fibroids on chromosome 1q43. Genomic map of a 2 Mb-long interval spanning the fumarate hydratase (FH) gene locus and showing the position of specific microsatellite markers (vertical bars) and gene loci linked or associated with diseases or traits of relevance to hormone-dependent tumors such as uterine leiomyomas. Quebec Family Study (QFS); sex hormone-binding globulin (SHBG); HERITAGE (HERITAGE Family Study). The placement of the genes in the gene map shown above the plot and the coordinates show below were derived the Human Genome assembly 19. Arrows indicate the orientation of the genes and are drawn proportionally to the size of the genes. RGS7 (regulator of G-protein 7); FH (fumarate hydratase); KMO (kynurenine 3-monooxygenase); OPN3 (opsin 3); WDR64 (WD repeat domain 64); EXO1 (exonuclease 1); MAP1LC3C (microtubule-associated protein 1 light chain 3 gamma); PLD5 (phospholipase D family, member 5).
Figure 2
Figure 2
Pattern of linkage disequilibrium (LD) between single nucleotide polymorphisms (SNPs) at risk for uterine fibroids and/or obesity in a case (panel a) and control (panel b) study of uterine fibroids in the National Institute of Environmental Health Sciences Uterine Fibroid Study. Note that in contrast to the ‘uterine leiomyoma (UL)' SNPs in the region downstream FH (SNP 656–673), which show low levels of or no LD with the two ‘obesity' SNPs, the association with SNP 1037, 1292 and 1335 is lost after controlling for body mass index (BMI). A full color version of this figure is available at the Journal of Human Genetics journal online.
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