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Review
. 2014 Jan;15(1):15-25.
doi: 10.1038/ni.2785.

NF-κB control of T cell development

Steve Gerondakis  1 , Thomas S Fulford  1 , Nicole L Messina  1 , Raelene J Grumont  1
Affiliations
Review

NF-κB control of T cell development

Steve Gerondakis et al. Nat Immunol. 2014 Jan.

Erratum in

Abstract

The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals.

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References

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