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. 2013 Jan;29(1):37-42.
doi: 10.12669/pjms.291.2694.

XRCC1 Arg280His polymorphism and glioma risk: A meta-analysis involving 1439 cases and 2564 controls

Liang Zhang  1 , Yan Wang  2 , Zhiqun Qiu  3 , Jiaohua Luo  4 , Ziyuan Zhou  5 , Weiqun Shu  6
Affiliations

XRCC1 Arg280His polymorphism and glioma risk: A meta-analysis involving 1439 cases and 2564 controls

Liang Zhang et al. Pak J Med Sci. 2013 Jan.

Abstract

Objectives: Previous reports indicated that XRCC1 Arg280His polymorphism might be a possible risk factor for several cancers. Published studies on the association of XRCC1 Arg280His polymorphisms with glioma risk have yielded controversial results. The present study aimed to derive a more precise estimation of the relationship.

Methodology: Meta-analyses assessing the association of XRCC1 Arg280His variation with glioma were conducted and subgroup analyses on ethnicity and source of controls were further performed. Eligible studies for the period up to May 2012 were identified.

Results: A total of four case-control studies comprising 1439 cases and 2564 controls were selected for analysis. The overall data indicated no significant association of XRCC1 Arg280His polymorphism with glioma risk (His vs Arg: OR=1.05; 95%CI=0.88-1.25; His/His vs Arg/Arg: OR=1.42; 95%CI=0.87-2.29; dominant model: OR=1.00; 95%CI=0.82-1.22; recessive model: OR=1.41; 95%CI=0.88-2.25). Likewise, in the subgroup analysis regarding ethnicity and source of controls, no associations were observed.

Conclusion: The results of the present study failed to suggest an association of XRCC1 Arg280His polymorphism with glioma risk. Further large and well-designed studies are needed to confirm this conclusion.

Keywords: Glioma; Malignancy; Meta-analysis; Polymorphism; Susceptibility; XRCC1 Arg280His.

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Figures

Fig.1
Fig.1
The flow diagram of included/excluded studies.
Fig.2
Fig.2
Meta-analysis for the association of glioma risk with XRCC1 Arg280His polymorphism. (His/His+His/Arg vs Arg/Arg); (a) Stratified by ethnicity; (b) Stratified by source of control.
Fig.3
Fig.3
Publication bias test for the overall data (His/His+His/Arg vs Arg/Arg). (a) Funnel plot; (b) Egger’s linear regression test.
See this image and copyright information in PMC

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