Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Feb;90(2):309-14.
doi: 10.1111/j.1476-5381.1987.tb08960.x.

Effect of somatostatin on 45Ca fluxes in guinea-pig isolated atria

J Díez, J Tamargo

Effect of somatostatin on 45Ca fluxes in guinea-pig isolated atria

J Díez et al. Br J Pharmacol. 1987 Feb.

Abstract

The effect of somatostatin (SS, 10(-6) M and 5 X 10(-6) M) was studied on 45Ca fluxes in guinea-pig isolated atria. SS produced a dose-dependent decrease in 45Ca uptake, this effect being dependent on the stimulation rate and Ca concentration in the bathing media. The decrease in 45Ca uptake was more evident at faster (60 and 180 beats min-1) than at slower frequencies (15 beats min-1) and was less evident in high Ca (5.4 mM). SS had no effect on 45Ca efflux. These results suggest that SS inhibits the slow inward Ca current in guinea-pig atrial fibres.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Physiol. 1968 Mar;195(2):451-70 - PubMed
    1. Annu Rev Physiol. 1973;35:55-86 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):49-68 - PubMed
    1. J Physiol. 1976 Jan;254(3):565-81 - PubMed
    1. Am J Physiol. 1978 Jul;235(1):C13-9 - PubMed

LinkOut - more resources