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. 2013 May;29(3):809-13.
doi: 10.12669/pjms.293.2982.

25-Hydroxyvitamin D is closely related with the function of the pancreatic islet β cells

Jingjing Guo  1 , Zhengda Xiao  2 , Xia Xue  3 , Xin Liu  4 , Yong Lu  5 , Xiao Yin  6 , Kun Ma  7
Affiliations

25-Hydroxyvitamin D is closely related with the function of the pancreatic islet β cells

Jingjing Guo et al. Pak J Med Sci. 2013 May.

Abstract

Objectives: This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet β cell function under different glucose tolerance statuses in China.

Methodology: Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group), and 160 normal control subjects (NGT group) were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment for insulin resistance (Homa-IR), insulin acuity index (IAI), β-cell function index (Homa-BCF) as well as secretion index (IS) were determined.

Results: The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group (P < 0.05). Homa-IR in DM group and IFG/IGT group was significantly higher than that in the NGT group (P < 0.05). Pearson correlation analysis and partial correlation analysis showed that 25-OH-D was positively correlated with fasting insulin (FINS) and Homa-BCF (P < 0.05). Multiple stepwise regression analysis showed that 25-OH-D was one of the influential factors of pancreatic islet β cell function in patients with type 2 diabetes mellitus.

Conclusions: Our results suggest that 25-OH-D is closely related with the function of the pancreatic islet β cells and is one of the influential factors of pancreatic islet β cell function.

Keywords: Diabetes mellius; Pancreatic islet β cell; Type 2; Vitamin D.

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References

    1. Baumgartl HJ, Standl E, Schmidt-Gayk H, Kolb HJ, Janka HU, Ziegler AG. Changes of vitamin D3 serum concentrations at the onset of immune-mediated type 1 (insulin-dependent) diabetes mellitus. Diabetes Res. 1999;16(3):145–148. - PubMed
    1. Ziegler AG, Walter M, Koczwara K. 1,25-Dihydroxyvitamin D3 for preservation of beta cell function in patients with newly diagnosed type 1 diabetes. 18th International diabetes federation congress; Paris. Poster Display. 2003;1457.
    1. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretions of insulin. Science. 1980;209(4458):823–825. - PubMed
    1. Santos RD, Vianna LM. Effect of cholecalciferol supplementation on blood glucose in an experimental model of type 2 diabetes mellitus in spontaneously hypertensive rats and Wistar rats. J Clin Chim Acta. 2005;358(1):146–150. - PubMed
    1. Palomer X, González-Clemente JM, Blanco-Vaca F. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008;10(3):185–197. - PubMed

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