Platelet receptors; an instrumental of platelet physiology

doi:10.12669/pjms.293.3497

Review

. 2013 May;29(3):891-6.

doi: 10.12669/pjms.293.3497.

Platelet receptors; an instrumental of platelet physiology

Muhammad Saboor¹, Qamar Ayub², Samina Ilyas³, Moinuddin⁴

Affiliations

¹ Muhammad Saboor, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.
² Qamar Ayub, Baqai Institute of Medical Technology, Baqai Medical University, Karachi, Pakistan.
³ SaminaIlyas, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.
⁴ Moinuddin, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.

PMID: 24353652
PMCID: PMC3809294
DOI: 10.12669/pjms.293.3497

Review

Platelet receptors; an instrumental of platelet physiology

Muhammad Saboor et al. Pak J Med Sci. 2013 May.

. 2013 May;29(3):891-6.

doi: 10.12669/pjms.293.3497.

Authors

Muhammad Saboor¹, Qamar Ayub², Samina Ilyas³, Moinuddin⁴

Affiliations

¹ Muhammad Saboor, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.
² Qamar Ayub, Baqai Institute of Medical Technology, Baqai Medical University, Karachi, Pakistan.
³ SaminaIlyas, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.
⁴ Moinuddin, Baqai Institute of Hematology, Baqai Medical University, Karachi, Pakistan.

PMID: 24353652
PMCID: PMC3809294
DOI: 10.12669/pjms.293.3497

Abstract

Platelets play an important role in hemostasis, inflammation, host defense, tumor growth and metastasis. Platelets receptors are instrumental in platelet-platelet aggregation and interaction of platelets with leukocytes, endothelial cells and coagulation factors. These receptors are also the targets for antiplatelet drugs. This review focuses on the role of platelet receptors in human physiology. Data were extracted from peer-reviewed journals using MEDLINE and EMBASE databases, and the following terms (platelets, platelet receptors, CD markers, integrins, tetraspanins, transmembrane receptors, prostaglandin receptors, immunoglobulin superfamily receptors) were used.

Keywords: Integrins; Platelet receptors; Selectins; Tetraspanins.

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References

1. Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 2003;24(6):327–334. - PubMed
1. Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis. 1997;25(5):951–968. - PubMed
1. Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, et al. Platelets actively sequester angiogenesis regulators. Blood. 2009;113(12):2835–2842. - PMC - PubMed
1. Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer cell. 2011;20(5):576–590. - PMC - PubMed
1. Clemetson KJ, Clemetson JM. Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 2008;99(3):473–479. - PubMed

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[1] Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 2003;24(6):327–334. - PubMed

[2] Muller WA. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 2003;24(6):327–334. - PubMed

[3] Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis. 1997;25(5):951–968. - PubMed

[4] Yeaman MR. The role of platelets in antimicrobial host defense. Clin Infect Dis. 1997;25(5):951–968. - PubMed

[5] Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, et al. Platelets actively sequester angiogenesis regulators. Blood. 2009;113(12):2835–2842. - PMC - PubMed

[6] Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, et al. Platelets actively sequester angiogenesis regulators. Blood. 2009;113(12):2835–2842. - PMC - PubMed

[7] Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer cell. 2011;20(5):576–590. - PMC - PubMed

[8] Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer cell. 2011;20(5):576–590. - PMC - PubMed

[9] Clemetson KJ, Clemetson JM. Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 2008;99(3):473–479. - PubMed

[10] Clemetson KJ, Clemetson JM. Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost. 2008;99(3):473–479. - PubMed

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Platelet receptors; an instrumental of platelet physiology

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Platelet receptors; an instrumental of platelet physiology

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