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. 2013 Sep;29(5):1108-11.
doi: 10.12669/pjms.295.3458.

The common causes leading to pancytopenia in patients presenting to tertiary care hospital

Kirpal Das Makheja  1 , Bharat Kumar Maheshwari  2 , Shafique Arain  3 , Suneel Kumar  4 , Sangeeta Kumari  5 , Vikash  6
Affiliations

The common causes leading to pancytopenia in patients presenting to tertiary care hospital

Kirpal Das Makheja et al. Pak J Med Sci. 2013 Sep.

Abstract

Objective: The objective of this study was to determine the frequency of common causes leading to Pancytopenia in patients presenting to tertiary care hospital at Karachi.

Methods: A total of 62 patients with the diagnosis of Pancytopenia of more than one week duration were enrolled in the study. All patients underwent a detailed medical history and full physical examination followed by blood sampling for the investigations i.e. complete blood count with peripheral film, erythrocyte sedimentation rate (ESR), Malarial parasites (MP), liver function test, Renal function tests, PT and viral profile (HBsAg, Anti-HCV), Ultrasonography of abdomen. All patients underwent bone marrow aspiration and trephine biopsy for reporting and interpretation. Duration of study was six months, from May 2010 to November 2010.

Results: The average age of the patients was 37.76 ± 16.38years. Out of 62 patients, 36 (58%) were male and 26 (42%) were female. Megaloblastic anemia was the commonest cause that was observed in 41.9% cases followed by acute myeloid leukemia 27.4%, aplastic anemia 19.4% and erythroid hyperplasia 11.3%. Conclusion : This study concluded that most common cause of pancytopenia is Megaloblastic anemia, followed by acute myeloid leukemia and aplastic anemia. Bone marrow examination is a single useful investigation which reveals the underlying cause in patients with pancytopenia.

Keywords: Aplastic Anemia; Bone Marrow Biopsy; Megaloblastic Anemia; Pancytopenia.

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Figures

Fig.1
Fig.1
Frequency of Common Causes of Pancytopenia
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References

    1. Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia a clinicohaematological study of 200 cases. Indian J Pathol Microbiol. 2002;45:375–379. - PubMed
    1. Shimamura A, Alter BP. Inherited aplastic anemia syndrome. In: Greer JP, Foerster J, Rodgers GM, Paraskevas F, Gladet B, Arber DA, et al.editors , editors. Wintrobe's clinical hematology. Philadelphia: Lippincott Williams & Wilkins; 2008. pp. 1173–11261.
    1. Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone marrow examination in cases of pancytopenia. J Nepal Med Assoc. 2008;47:12–17. - PubMed
    1. Imbert M, Scoazec JY, Mary JY, Jouzult H, Rochant H, Sultan C. Adult patients presenting with pancytopenia: a reappraisal of underlying pathology and diagnostic procedures in 213 cases. Hematol Pathol. 1989;3:159–167. - PubMed
    1. Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Trop Geogr Med. 1992;44:322–327. - PubMed

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