Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Summer;17(3):e112-3.
doi: 10.7812/TPP/12-071.

Mixed cryoglobulinemia: an unusual presentation of hepatitis C

Donald Mebust  1
Affiliations
Case Reports

Mixed cryoglobulinemia: an unusual presentation of hepatitis C

Donald Mebust. Perm J. 2013 Summer.

Abstract

A 50-year-old man with a history of hepatitis C presented with recurrent episodes of abdominal pain, arthralgia, and weakness. Although these symptoms seemed rather non-specific, a purpuric rash of the lower extremities was the final clue to diagnosis. The diagnosis was then confirmed by histopathologic and serologic testing.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Image of purpuric rash of lower extremities.
See this image and copyright information in PMC

References

    1. Wintrobe MM, Buell MV. Hyperproteinemia associated with multiple myeloma. Bull Johns Hopkins Hosp. 1933;52:156–65.
    1. Lerner AB, Watson CJ. Studies of cryoglobulins; unusual purpura associated with the presence of a high concentration of cryoglobulin (cold precipitable serum globulin) Am J Med Sci. 1947 Oct;214(4):410–5. DOI: http://dx.doi.org/10.1097/00000441-194710000-00009. - DOI - PubMed
    1. Meltzer M, Franklin EC. Cryoglobulinemia—a study of twenty-nine patients. IgG and IgM cryoglobulins and factors effecting cryoprecipitability. Am J Med. 1966 Jun;40(6):828–36. DOI: http://dx.doi.org/10.1016/0002-9343(66)90199-9. - DOI - PubMed
    1. Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M. Biological and clinical significance of cryoglobulins. A report of 86 cases. Am J Med. 1974 Nov;57(5):775–88. DOI: http://dx.doi.org/10.1016/0002-9343(74)90852-3. - DOI - PubMed
    1. Horcajada JP, García-Bengoechea M, Cilla G, Etxaniz P, Cuardrado E, Arenas JI. Mixed cryoglobulinemia in patients with chronic hepatitis C infection: prevalence, significance and relationship with different viral genotypes. Ann Med. 1999 Oct;31(5):352–8. DOI: http://dx.doi.org/10.3109/07853899908995902. - DOI - PubMed

Publication types

LinkOut - more resources