Lin28a--boost your energy for youthful regeneration
- PMID: 24357531
- PMCID: PMC3990678
- DOI: 10.1002/embj.201387363
Lin28a--boost your energy for youthful regeneration
Abstract
The regenerative capacity of most tissues declines dramatically after embryonic development and during post-natal life. The underlying mechanisms of this phenomenon are incompletely understood. In a recent issue of Cell, Shyh-Chang and colleagues provide experimental evidence that Lin28 prolongs youthful regenerative capacity by increasing oxidative glucose metabolism (Shyh-Chang et al, 2013).
Comment on
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Lin28 enhances tissue repair by reprogramming cellular metabolism.Cell. 2013 Nov 7;155(4):778-92. doi: 10.1016/j.cell.2013.09.059. Cell. 2013. PMID: 24209617 Free PMC article.
References
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- Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 2007;39:99–105. - PubMed
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