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Comment
. 2013 Dec 20;15(6):321.
doi: 10.1186/bcr3590.

Cancer dormancy: time to explore its clinical relevance

Miodrag Gužvić, Christoph A Klein
Comment

Cancer dormancy: time to explore its clinical relevance

Miodrag Gužvić et al. Breast Cancer Res. .

Abstract

Dormant disseminated cancer cells, arrested and nonproliferating, are "good" cancer cells because there is no need to worry unless they resume growth. The mechanisms by which dormant disseminated cancer cells are put to sleep at distant sites and re-awakened are poorly understood. Moreover, it is not clear whether re-awakened cancer cells have a role in disease courses. Cyrus Ghajar and colleagues identified a mechanism of dormancy and growth resumption that might become important when more closely linked to clinical reality.

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  • The perivascular niche regulates breast tumour dormancy.
    Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ. Ghajar CM, et al. Nat Cell Biol. 2013 Jul;15(7):807-17. doi: 10.1038/ncb2767. Epub 2013 Jun 2. Nat Cell Biol. 2013. PMID: 23728425 Free PMC article.

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