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Editorial
. 2014 Jan;210(1):3-11.
doi: 10.1016/j.ajog.2013.11.020.

A role for sleep disorders in pregnancy complications: challenges and opportunities

Roberto Romero  1 , M Safwan Badr  2
Affiliations
Editorial

A role for sleep disorders in pregnancy complications: challenges and opportunities

Roberto Romero et al. Am J Obstet Gynecol. 2014 Jan.
No abstract available

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. Mortality hazard ratios according to sleep duration for men and women
Data collected from 636,095 men and 480,841 women in the Cancer Prevention Study II (1982-1988). Both men and women with usual sleep duration of 7 hours had the best survival. Participants reporting sleep durations ≤ 6 hours and ≥ 8 hours had significantly increased mortality hazard. Reproduced, with permission, from Luyster et al.
Figure 2
Figure 2. Pathway to clear cellular waste from the brain using the glymphatic system
Cerebrospinal fluid (CSF) passes through the para-arterial space surrounding the arteries (top part of the Figure). This space is bound by the non-luminal surface of the blood vessel and the apical processes of astrocytes. Aquaporin-4 (AQP4) is a water channel that facilitates convective flow out of the para-arterial space into the interstitial space. CSF exchanges with interstitial fluid (ISF) and generates a convective flow that clears the waste using a paravenous route. Reproduced with permission from the American Association for the Advancement of Science, from Nedergaard.
Figure 3
Figure 3. Cerebral spinal fluid influx in a murine model
Difference of cerebral spinal fluid influx in the brain of a sleeping (left) and awake (right) mouse. Fluorescent dye was injected to enable the study of cerebral spinal fluid dynamics in a live mouse using 2-photon imaging. Red represents greater flow in a sleeping animal. Green indicates decreased flow in the awake animal. Images provided by Drs. Maiken Nedergaard and Lulu Xie of the Division of Glial Disease and Therapeutics, Center for Translational Medicine, Department of Neurosurgery, University of Rochester Medical Center. The work was funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke.
Figure 4
Figure 4. Maternal mean plasma glucose concentrations after a 50-g glucose challenge
Means are adjusted for maternal age and race/ethnicity. Error bars are SE. Open access article. Qiu et al.
See this image and copyright information in PMC

Comment on

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