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Comparative Study
. 1987 Jan;7(1):41-7.
doi: 10.1128/mcb.7.1.41-47.1987.

Characterization of cDNA clones for the human c-yes gene

J Sukegawa, K Semba, Y Yamanashi, M Nishizawa, N Miyajima, T Yamamoto, K Toyoshima
Comparative Study

Characterization of cDNA clones for the human c-yes gene

J Sukegawa et al. Mol Cell Biol. 1987 Jan.

Abstract

Three c-yes cDNA clones were obtained from poly(A)+ RNA of human embryo fibroblasts. Sequence analysis of the clones showed that they contained inserts corresponding to nearly full-length human c-yes mRNA, which could encode a polypeptide of 543 amino acids with a relative molecular weight (Mr) of 60,801. The predicted amino acid sequence of the protein has no apparent membrane-spanning region or suspected ligand binding domain and closely resembles pp60c-src. Comparison of the sequences of c-yes and v-yes revealed that the v-yes gene contains most of the c-yes coding sequence except the region encoding its extreme carboxyl terminus. The region missing from the v-yes protein is the part that is highly conserved in cellular gene products of the protein-tyrosine kinase family.

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References

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