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. 1987;326(6111):358-63.
doi: 10.1038/326358a0.

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

P M Colman, W G Laver, J N Varghese, A T Baker, P A Tulloch, G M Air, R G Webster

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

P M Colman et al. Nature. 1987.

Abstract

The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of antigen-antibody binding. The structure of the antigen changes on binding, and that of the antibody may also change; the interaction therefore has some of the character of a handshake.

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