Holocarboxylase synthetase: a multitalented protein with roles in biotin transfer, gene regulation and chromatin dynamics

Affiliations

¹ Departments of Biochemistry & Molecular Biology and of Medical Genetics and the Alberta Children's Hospital Research Institute for Child and Maternal Health, Faculties of Medicine and Kinesiology, University of Calgary, Room 250 Heritage Medical Research Building, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T3H-1C1. Electronic address: rgravel@ucalgary.ca.

Comment

Roy A Gravel. Mol Genet Metab. 2014 Mar.

. 2014 Mar;111(3):305-306.

doi: 10.1016/j.ymgme.2013.11.010. Epub 2013 Dec 1.

¹ Departments of Biochemistry & Molecular Biology and of Medical Genetics and the Alberta Children's Hospital Research Institute for Child and Maternal Health, Faculties of Medicine and Kinesiology, University of Calgary, Room 250 Heritage Medical Research Building, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T3H-1C1. Electronic address: rgravel@ucalgary.ca.

No abstract available

Keywords: Biotin; Chromatin; Histone deacetylase; Holocarboxylase synthetase; Regulation.

Comment on

Holocarboxylase synthetase acts as a biotin-independent transcriptional repressor interacting with HDAC1, HDAC2 and HDAC7.
Trujillo-Gonzalez I, Cervantes-Roldan R, Gonzalez-Noriega A, Michalak C, Reyes-Carmona S, Barrios-Garcia T, Meneses-Morales I, Leon-Del-Rio A. Trujillo-Gonzalez I, et al. Mol Genet Metab. 2014 Mar;111(3):321-330. doi: 10.1016/j.ymgme.2013.10.016. Epub 2013 Nov 2. Mol Genet Metab. 2014. PMID: 24239178