Experimentation with inhaled bronchodilators and corticosteroids

Abstract

Background: Inhaled bronchodilators and corticosteroids have been used for decades with different production systems.

Materials and methods: The following jet-nebulizers: (a) Invacare, (b) Sunmist, (c) Maxineb and ultrasound nebulizers: (a) GIMA, (b) OMRON and (c) EASY NEB II were used as production systems. The jet-nebulizers were used with different residual cups and volume filling, while the ultrasound nebulizers with different volume fillings and face mask versus inlet.

Results: Inhalation and ultrasound process detect significant differences between the factors and interactions considered, but each technique follows a specific pattern of magnitude effect. Thus the inhaled mechanism ranks the factor effects in decreasing order: residual cup>drug>nebulizer>loading (2, 3, 4 ml) and also drug>residual cup>nebulizer (loading 8 ml). The ultrasound mechanism orders as follows: nebulizer>drug>loading. In fact, varying micro environmental conditions created during the performance of the devices in both processes alternate the magnitude of factor significance allowing for unique capacities.

Conclusions: PULMICORT, MAXINEB, design cup J and loading 6 ml are the best options for the inhaled process. Optimal combinations are provided by FLIXOTIDE and cup B and also by MAXINEB and cup J. The incorporation of large residual cups suggests one out of six drugs, the SUNMIST nebulizer and design D as the best choices. Ultrasound performance informs for other optimal conditions: ZYLOREN, MAXINEB, 4 ml load and MAXINEB×loading 4 ml.

Keywords: Aerolin (Pub Chem CID: 39859); Anticholinergic; Beclomethasone Dipropionate (Pub Chem CID: 21700); Bronchodilators; Budesonide (Pub Chem CID: 5281004); Carboplatin (Pub Chem CID: 10339178); Cisplatin (Pub Chem CID: 83910); Corticosteroids; Docetaxel (Pub Chem CID: 148124); Gemcitabine (Pub Chem CID: 60749); Ipratropium Bromide (Pub Chem CID: 657308); Nebulizers; Paclitaxel (Pub Chem CID: 36314); Sulbactam (Pub Chem CID: 130313).