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Review
. 2014 Jul-Aug;32(4):679-92.
doi: 10.1016/j.biotechadv.2013.11.012. Epub 2013 Dec 19.

Interaction of stable colloidal nanoparticles with cellular membranes

Morteza Mahmoudi  1 , Jie Meng  2 , Xue Xue  2 , Xing Jie Liang  2 , Masoud Rahman  3 , Christian Pfeiffer  4 , Raimo Hartmann  4 , Pilar Rivera Gil  4 , Beatriz Pelaz  4 , Wolfgang J Parak  5 , Pablo Del Pino  5 , Susana Carregal-Romero  6 , Antonios G Kanaras  7 , Subramanian Tamil Selvan  8
Affiliations
Review

Interaction of stable colloidal nanoparticles with cellular membranes

Morteza Mahmoudi et al. Biotechnol Adv. 2014 Jul-Aug.

Abstract

Due to their ultra-small size, inorganic nanoparticles (NPs) have distinct properties compared to the bulk form. The unique characteristics of NPs are broadly exploited in biomedical sciences in order to develop various methods of targeted drug delivery, novel biosensors and new therapeutic pathways. However, relatively little is known in the negotiation of NPs with complex biological environments. Cell membranes (CMs) in eukaryotes have dynamic structures, which is a key property for cellular responses to NPs. In this review, we discuss the current knowledge of various interactions between advanced types of NPs and CMs.

Keywords: Cell membrane; Colloid; Nanoparticle; Protein corona; Receptor; Targeted delivery.

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