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Review
. 2014 Feb 21;289(8):4571-7.
doi: 10.1074/jbc.R113.509588. Epub 2013 Dec 20.

The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies

Zachary S Scheiner  1 , Sohel Talib, Ellen G Feigal
Affiliations
Review

The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies

Zachary S Scheiner et al. J Biol Chem. .

Abstract

Induced pluripotent stem cell (iPSC) technology offers the promise of immune-matched cell therapies for a wide range of diseases and injuries. It is generally assumed that cells derived from autologous iPSCs will be immune-privileged. However, there are reasons to question this assumption, including recent studies that have tested iPSC immunogenicity in various ways with conflicting results. Understanding the risk of an immune response and developing strategies to minimize it will be important steps before clinical testing. Here, we review the evidence for autologous iPSC immunogenicity, its potential causes, and approaches for assessment and mitigation.

Keywords: Cell Therapy; Cellular Immune Response; Humoral Response; Induced Pluripotent Stem Cells; Innate Immunity; iPSC.

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